KEGG   REACTION: R02661
Entry
R02661                      Reaction                               
Name
2-methylpropanoyl-CoA:(acceptor) 2,3-oxidoreductase
Definition
2-Methylpropanoyl-CoA + Acceptor <=> 2-Methylprop-2-enoyl-CoA + Reduced acceptor
Equation
C00630 + C00028 <=> C03460 + C00030
Reaction class
RC00148  C00630_C03460
Enzyme
1.3.8.1         1.3.8.5         1.3.8.7         1.3.99.-
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.8  With a flavin as acceptor
    1.3.8.1
     R02661  2-Methylpropanoyl-CoA + Acceptor <=> 2-Methylprop-2-enoyl-CoA + Reduced acceptor
    1.3.8.5
     R02661  2-Methylpropanoyl-CoA + Acceptor <=> 2-Methylprop-2-enoyl-CoA + Reduced acceptor
    1.3.8.7
     R02661  2-Methylpropanoyl-CoA + Acceptor <=> 2-Methylprop-2-enoyl-CoA + Reduced acceptor
   1.3.99  With unknown physiological acceptors
    1.3.99.-
     R02661  2-Methylpropanoyl-CoA + Acceptor <=> 2-Methylprop-2-enoyl-CoA + Reduced acceptor
Orthology
K00248  butyryl-CoA dehydrogenase [EC:1.3.8.1]
K00249  acyl-CoA dehydrogenase [EC:1.3.8.7]
K09478  short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5]
K11410  short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5]
K11538  isobutyryl-CoA dehydrogenase [EC:1.3.99.-]
Reference
1  [PMID:12359132]
  Authors
Nguyen TV, Andresen BS, Corydon TJ, Ghisla S, Abd-El Razik N, Mohsen AW, Cederbaum SD, Roe DS, Roe CR, Lench NJ, Vockley J
  Title
Identification of isobutyryl-CoA dehydrogenase and its deficiency in humans.
  Journal
Mol Genet Metab 77:68-79 (2002)
DOI:10.1016/S1096-7192(02)00152-X
Reference
2  [PMID:11013134]
  Authors
Andresen BS, Christensen E, Corydon TJ, Bross P, Pilgaard B, Wanders RJ, Ruiter JP, Simonsen H, Winter V, Knudsen I, Schroeder LD, Gregersen N, Skovby F
  Title
Isolated 2-methylbutyrylglycinuria caused by short/branched-chain acyl-CoA dehydrogenase deficiency: identification of a new enzyme defect, resolution of its molecular basis, and evidence for distinct acyl-CoA dehydrogenases in isoleucine and valine metabolism.
  Journal
Am J Hum Genet 67:1095-103 (2000)
DOI:10.1086/303105
Other DBs
RHEA: 31098

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (4)   
   KEGG ENZYME (3)   
   KEGG RCLASS (1)   
Gene (17900)   
   KEGG ORTHOLOGY (5)   
   KEGG GENES (17895)   
All databases (17913)   

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